NIPH Clinical Trials Search

JAPANESE
国立保健医療科学院
UMIN ID: UMIN000000652

Registered date:01/11/2008

Effects of Low Density Lipoprotein Apheresis on Oxidative Stress and Endothelial/Vascular Smooth Muscle Cell Function in Patients with Peripheral Arterial Disease and End-stage Renal Disease

Basic Information

Recruitment status Complete: follow-up complete
Health condition(s) or Problem(s) studiedperipheral artery disease, end-stage renal disease on hemodialysis
Date of first enrollment2007/02/01
Target sample size50
Countries of recruitmentJapan
Study typeObservational
Intervention(s)

Outcome(s)

Primary Outcome1. Clinical papameters 1) Signs & symptoms (pain at rest, intermittent claudication, walking distance) 2) Blood biochemistry (serum lipid including total cholesterol and LDL, coaglatory factors including fibrinogen, CRP, oxidised LDL, MDA-LDL, AGE, VEGF, HGF). 3) ABI/baPWV 2. Vascular cell functions 1) Human vascular endothelial cells (commercially available) (ecNOS expression, proliferative activity, tube formation activity) 2) Human vascular smooth muscle cells (commercially available)(expressions of AT1 receptor and its interacting molecule ATRAP, growth factors, extracellular matrix, proliferation activity).
Secondary Outcome

Key inclusion & exclusion criteria

Age minimum20years-old
Age maximum80years-old
GenderMale and Female
Include criteria
Exclude criteriaExclusion criteria: 1. Poor controlled diabetics, 2. Poor controlled hypertensives, 3. Moderate to severe liver dysfunction, 4. Judged as unsuitable from other reasons.

Related Information

Contact

public contact
Name Kazuaki Uchino
Address 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, JAPAN Japan
Telephone 045-787-2635
E-mail uchinok@med.yokohama-cu.ac.jp
Affiliation Yokohama City University School of Medicine Department of Cardiorenal Medicine
scientific contact
Name Kouichi TAMURA
Address 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, JAPAN Japan
Telephone 045-787-2635
E-mail tamukou@med.yokohama-cu.ac.jp
Affiliation Yokohama City University School of Medicine Department of Cardiorenal Medicine