UMIN ID: UMIN000000558
Registered date:10/01/2007
Study on diagnosis of Alzheimer disease by amyloid imaging: A multi-center trial
Basic Information
| Recruitment status | Complete: follow-up complete |
|---|---|
| Health condition(s) or Problem(s) studied | Healthy normal volunteers, Mild cognitive impairment (MCI), Alzheimer disease (AD) |
| Date of first enrollment | 2006/10/01 |
| Target sample size | 80 |
| Countries of recruitment | Japan |
| Study type | Observational |
| Intervention(s) |
Outcome(s)
| Primary Outcome | The molecular PET imaging using [11C]BF-227. The [11C]BF-227-PET is evaluated by cortical SUV ratios to cerebellum as a reference among healthy volunteers, mild cognitive impairment, and Alzheimer patients. |
|---|---|
| Secondary Outcome | The comparison of FDG-PET, MRI, psychological cognitive tests, and [11C]BF-227-PET among healthy volunteers, mild cognitive impairment, and Alzheimer patients. The [11C]BF-227-PET is evaluated by cortical SUV ratios to cerebellum as a reference |
Key inclusion & exclusion criteria
| Age minimum | 35years-old |
|---|---|
| Age maximum | Not applicable |
| Gender | Male and Female |
| Include criteria | |
| Exclude criteria | 1)The past and present history of alcoholism. 2)The past and present history of epilepsy 3)Education period is less than 6 years. 4)There are no persons who can give any information on patients symptoms. 5)Diabetic patients treated with insulin 6)Patients treated with antidepressants, antipsychotics, and long-term sedative-hypnotics. 7)Severe complication including malignancy, heart failure, hepatic dysfunction, renal dysfunction, endocrine disorders, etc. 8)Other patients and volunteers that investigators and medical doctors need to exclude. |
Related Information
| Primary Sponsor | Study Group on diagnosis of Alzheimer disease by amyloid imaging using [11C]BF-227 |
|---|---|
| Secondary Sponsor | 1)Department of Geriatrics and Gerontology, Tohoku University School of medicine 2)Cyclotron and Radioisotope Center, Tohoku University |
| Source(s) of Monetary Support | A Grant-in Aid for Research on nano-medicine from the Ministry of Health and Welfare, Japan (2006-2008) |
| Secondary ID(s) |
Contact
| public contact | |
| Name | Dr. Nobuyuki Okamura |
| Address | Seiryo-machi 2-1, Aoba-Ku, Sendai 980-8575, Japan Japan |
| Telephone | 022-717-8058 |
| yanai@med.tohoku.ac.jp | |
| Affiliation | Tohoku University Graduate School of Medicine Department of Pharmacology |
| scientific contact | |
| Name | Professor Kazuhiko Yanai |
| Address | Seiryo-machi 2-1, Aoba-Ku, Sendai 980-8575, Japan Japan |
| Telephone | 022-717-8055 |
| Affiliation | Tohoku University Graduate School of Medicine Department of Pharmacology |