NIPH Clinical Trials Search

UMIN ID: UMIN000000480

Registered date:26/09/2006

The randomized controlled trial about the regression of atherosclerosis by using pioglitazone added to statin treatment

Basic Information

Recruitment status Complete: follow-up complete
Health condition(s) or Problem(s) studiedcoronary artery disease
Date of first enrollment2006/10/01
Target sample size30
Countries of recruitmentJapan
Study typeInterventional
Intervention(s)15 to 45mg pioglitazone is administered for the patient for six months once per day added to statin therapy statin therapy only


Primary Outcomecarotid intima-media thickness by carotid artery echo if possible, coronary angiography and intravascular ultrasound
Secondary Outcome

Key inclusion & exclusion criteria

Age minimum20years-old
Age maximum80years-old
GenderMale and Female
Include criteria
Exclude criteriaanamnesis of cardiac insufficiency LVEF<40% critical hepatopathy(an increase the twice as many fiducial point of AST,ALT, ALP,etc, and choloplania) renal dysfunction(more than serum creatine 2.0mg/dl) anaphylactic anamnesis to piogritazon critical trauma, preoperative, serious infectious desease, pregnancy

Related Information


public contact
Address Japan
Affiliation Kumamoto University hospital cardiovascular medicine
scientific contact
Name Hisao Ogawa
Address 1-1-1 Honjo, Kumamoto City, Kumamoto, Japan Japan
Affiliation Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University cardiovascular medicine