NIPH Clinical Trials Search

JAPANESE
国立保健医療科学院
UMIN ID: UMIN000000469

Registered date:01/09/2006

Study on pleiotropic effects of angiotensin II- receptor blockers (ARB) in hypertensive obese patients.

Basic Information

Recruitment status Complete: follow-up continuing
Health condition(s) or Problem(s) studiedHypertension
Date of first enrollment2004/12/01
Target sample size150
Countries of recruitmentJapan
Study typeInterventional
Intervention(s)Normal dosage of telmisartan is administered for 6 months after randomization Normal dosage of valsartan is administered for 6 months after randomization Normal dosage of candesartan is administered for 6 months after randomization

Outcome(s)

Primary OutcomeChange in fasting plasma glucose and insulin levels Change in serum lipid profile Change in high-sensitive CRP
Secondary OutcomeChange in serum adiponectin level Change in serum AGE-2

Key inclusion & exclusion criteria

Age minimum30years-old
Age maximum70years-old
GenderMale and Female
Include criteria1. Patients with obesity whose BMI exceeding 25 2. Patients with hypertension (Systolic blood pressure is >=140 or diastolic >=90)
Exclude criteria-patients with secondary hypertension -patients whose AST or ALT exceeding 100IU/L -patients with bile stenosis -patients with severe renal failure or nephrotic syndrome -patients with severe cerebral infarction -pregnant women or those who plan pregnancy, or in the lactation period -patients with neoplasm -patients with history of hypersensitivity to telmisartan, valsartan, or candesartan -other patients judged unsuitable for the study by the investigator

Related Information

Contact

public contact
Name Masanari Mizuta
Address 5200 Kihara, Kiyotake, Miyazaki 889-1692 Japan
Telephone 0985-85-2965
E-mail mmizuta@fc.miyazaki-u.ac.jp
Affiliation Department of Internal Medicine, University of Miyazaki Faculty of Medicine Neurology, Respirology, Endocrinology and Metabolism
scientific contact
Name Masamitsu Nakazato
Address 5200 Kihara, Kiyotake, Miyazaki 889-1692 Japan
Telephone 0985-85-2965
E-mail
Affiliation Department of Internal Medicine, University of Miyazaki Faculty of Medicine Neurology, Respirology, Endocrinology and Metabolism