Study on pleiotropic effects of angiotensin II- receptor blockers (ARB) in hypertensive obese patients.

UMIN ID: UMIN000000469

Registered date:01/09/2006

Basic Information

• Recruitment status: Complete: follow-up continuing
• Health condition(s) or Problem(s) studied: Hypertension
• Date of first enrollment: 2004/12/01
• Target sample size: 150
• Countries of recruitment: Japan
• Study type: Interventional

Intervention(s)

Normal dosage of telmisartan is administered for 6 months after randomization
Normal dosage of valsartan is administered for 6 months after randomization
Normal dosage of candesartan is administered for 6 months after randomization

Outcome(s)

• Primary Outcome: Change in fasting plasma glucose and insulin levels Change in serum lipid profile Change in high-sensitive CRP
• Secondary Outcome: Change in serum adiponectin level Change in serum AGE-2

Key inclusion & exclusion criteria

• Age minimum: 30years-old
• Age maximum: 70years-old
• Gender: Male and Female
• Exclude criteria: -patients with secondary hypertension -patients whose AST or ALT exceeding 100IU/L -patients with bile stenosis -patients with severe renal failure or nephrotic syndrome -patients with severe cerebral infarction -pregnant women or those who plan pregnancy, or in the lactation period -patients with neoplasm -patients with history of hypersensitivity to telmisartan, valsartan, or candesartan -other patients judged unsuitable for the study by the investigator

Related Information

• Primary Sponsor: 3M STUDY GROUP
• Source(s) of Monetary Support: None