Metabolic effect of telmisartan and losartan in peritoneal dialysis patients

UMIN ID: C000000383

Registered date:31/03/2006

Basic Information

• Recruitment status: Complete: follow-up complete
• Health condition(s) or Problem(s) studied: peritoneal dialysis patients
• Date of first enrollment: 2006/03/01
• Target sample size: 30
• Countries of recruitment: Japan
• Study type: Interventional
• Intervention(s): losartan(25mg or 50mg twice a day) for 3 months,then telmisartan(20mg or 40 mg twice a day)for 3 months,then losartan(25mg or 50mg twice a day) for 3 months

Outcome(s)

• Primary Outcome: effect on lipid profile and insulin sensitivity;waist,BMI,T-Cho,TG,LDL-C,leptin,HOMA-IR,values of glucose and insulin in the oral glucose tolerance test
• Secondary Outcome: 1)effect on inflammation;serum hsCRP,IL- 6,TNFarfa 2)effect on blood pressure;ambulatory blood pressure monitoring 3)effect on residual renal function; renal Ccr,urine protein

Key inclusion & exclusion criteria

• Age minimum: Not applicable
• Age maximum: Not applicable
• Gender: Male and Female
• Exclude criteria: 1)morning blood pressure < 125/75mmHg in a sitting position without any antihypertensive 2)patients with hyperkalemia(K>6.0 mEq/l)

Related Information

• Primary Sponsor: Department of Internal Medicine,Osaka University School of Medicine Devision of Nephrology
• Source(s) of Monetary Support: Boehringer ingelheim