UMIN ID: C000000371
Registered date:01/09/2006
Effects of Atorvastatin on Reducing F-FDG Accumulation in Atherosclerotic Plaques: Using PET Imaging Study: pilot phase
Basic Information
| Recruitment status | Complete: follow-up complete |
|---|---|
| Health condition(s) or Problem(s) studied | Patients with hyperlipidemia, who are going to undergo percutaneous coronary intervention for treatment of stable angina pectoris |
| Date of first enrollment | 2006/03/01 |
| Target sample size | 30 |
| Countries of recruitment | Japan |
| Study type | Interventional |
| Intervention(s) | Patients are given low doses (5 mg/day) atorvastatin for 6 months, starting immediately after PCI Patients are given high doses (20 mg/day) atorvastatin for 6 months, starting immediately after PCI |
Outcome(s)
| Primary Outcome | Changes in the F-FDG-accumulation rate (plaque/integral plasma) at 6 months after PCI from baseline (both absolute value and % changes) |
|---|---|
| Secondary Outcome |
Key inclusion & exclusion criteria
| Age minimum | 30years-old |
|---|---|
| Age maximum | 70years-old |
| Gender | Male and Female |
| Include criteria | |
| Exclude criteria | 1)Patients with impaired glucose tolerance or diabetes mellitus 2)Patients with serum Cr>2mg/dl 3)Patients with acute coronary syndrom 4)Patients who are treated with any lipid-lowering drugs (statins, fibrates and/or nicotinic acid) before enrollment |
Related Information
| Primary Sponsor | Department of Cardiology, Nagoya University School of Medicine |
|---|---|
| Secondary Sponsor | |
| Source(s) of Monetary Support | Self funding |
| Secondary ID(s) |
Contact
| public contact | |
| Name | |
| Address | Japan |
| Telephone | |
| y-ogawa@med.nagoya-u.ac.jp | |
| Affiliation | Nagoya University School of Medicine Department of Cardiology |
| scientific contact | |
| Name | Hideki Ishii |
| Address | 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, Japan Japan |
| Telephone | |
| Affiliation | Nagoya University School of Medicine Department of Cardiology |