The Effect of Losartan and Amlodipine on Left Ventricular Diastolic Function in Patients With Mild-to-Moderate Hypertension

UMIN ID: C000000319

Registered date:01/02/2006

Basic Information

• Recruitment status: Complete: follow-up complete
• Health condition(s) or Problem(s) studied: Hypertensive heart disease
• Date of first enrollment: 2005/03/01
• Target sample size: 300
• Countries of recruitment: Japan
• Study type: Interventional

Intervention(s)

treatment with angiotensin II type 1 receptor blocker
treatment with calcium channel blocker

Outcome(s)

• Primary Outcome: LV diastolic function
• Secondary Outcome: carotid artery atherosclerosis BNP PIIIP CITP high sensitivity C-reactive protein

Key inclusion & exclusion criteria

• Age minimum: 20years-old
• Age maximum: Not applicable
• Gender: Male and Female
• Exclude criteria: •History of a life-threatening adverse event induced by ARB or CCB •Pregnant woman •Serious liver dysfunction (aspartate aminotransferase or alanine aminotransferase more than 10 times of normal upper limit) •Serum creatinine > 1.8 mg/dl, known bilateral renal artery stenosis, single kidney, renal sclerosis •Secondary hypertension, malignant hypertension, hypertensive encephalopathy •Cardiovascular or cerebrovascular accidents within the last 6 months •Patients with angina pectoris who need CCB or beta-blocker •Significant aortic stenosis (peak transaortic valve pressure gradient > 20 mmHg) •Important aortic or mitral regurgitation in the investigators opinion •Patients with other diseases which affect the serum levels of carboxy-terminal telopeptide of collagen type I (CITP) and carboxy-terminal of procollagen type III (PIIIP) •Prescription of ACEI or ARB within 5 months •Prescription of beta-blocker or CCB within 4 weeks

Related Information

• Primary Sponsor: J-ELAN study group
• Source(s) of Monetary Support: Osaka Heart Club