Evaluating safety and efficacy of low dose monteplase and nicorandil injected before percutaneous coronary intervention on left ventricular wall motion in patients of acute myocardial infarction:a randomized study.

UMIN ID: C000000229

Registered date:14/09/2005

Basic Information

• Recruitment status: Complete: follow-up complete
• Health condition(s) or Problem(s) studied: Acute myocardial infarction
• Date of first enrollment: 1999/11/01
• Target sample size: 88
• Countries of recruitment: Japan
• Study type: Interventional

Intervention(s)

Both Monteplase,15000u per kg,and Nicorandil,4mg bolus injection and 96mg per day continuous injection,are injected.
Monteplase but no Nicorandil are injected
Nicorandil but no Monteplase are injected
Neither Monteplase nor Nicorandil are injected

Outcome(s)

• Primary Outcome: Left ventricular wall motion,event of heart failure,death and re-infarction,bleeding complication,time to recanalization,angiographical data,serum CPK and CKMB
• Secondary Outcome: Restenosis of infarcted artery

Key inclusion & exclusion criteria

• Age minimum: 20years-old
• Age maximum: 75years-old
• Gender: Male and Female
• Exclude criteria: Severe hepatic or renal dysfunction,anemia,restricted to use Monteplase or Nicorandil and to treat by PCI.

Related Information

• Primary Sponsor: Chiba Emergency Medical Center
• Source(s) of Monetary Support: Chiba Emergency Medical Center