Japanese Extracranial-Intracranial Arterial Bypass Trial

UMIN ID: C000000144

Registered date:08/09/2005

Basic Information

• Recruitment status: Complete: follow-up complete
• Health condition(s) or Problem(s) studied: Symptomatic internal carotid artery or middle cerebral artery occlusion or stenosis
• Date of first enrollment: 1998/11/01
• Target sample size: 280
• Countries of recruitment: Japan
• Study type: Interventional

Intervention(s)

Medically-treated group (antiplatelet drug: ticlopidine and/or aspirin)
Surgically-treated group (arterial bypass surgery with medication of antiplatelet drug)

Outcome(s)

• Primary Outcome: 1) Completed stroke (Rankin disability scale 3, 4 or 5). 2) Major cardiovascular morbidity and death. 3) Other cause of death and severe disability. 4) Patients who are necessary to undergo additional procedures or a second EC/IC bypass on the same side.
• Secondary Outcome: Completed stroke (Rankin disability scale 3, 4 or 5) due to the occlusive artery enrolled into the study.

Key inclusion & exclusion criteria

• Age minimum: 20years-old
• Age maximum: 73years-old
• Gender: Male and Female
• Exclude criteria: 1) Rankin disability scale 3,4,5. 2) non-atherosclerotic lesion. 3) patients with malignant neoplasm, renal failure, cardiac failure, hepatic failure or lung failure. 4) myocardial infarction within six months. 5) diabetus mallitus with FBS more than 300 mg/dl or during treatment using insulin. 6) diastolic arterial pressure more than 110 mmHg.7) artery to artery embolism, 8) cardioembolism

Related Information

• Primary Sponsor: JET Study Group
• Source(s) of Monetary Support: National Cardiovascular Center