NIPH Clinical Trials Search

UMIN ID: C000000089

Registered date:31/08/2005

Japan-Working Groups of Acute Myocardial Infarction for the Reduction of Necrotic Damage by a K-ATP

Basic Information

Recruitment status Complete: follow-up complete
Health condition(s) or Problem(s) studiedPatients with AMI who are candidates for PCI(first episode of AMI)
Date of first enrollment2001/10/01
Target sample size600
Countries of recruitmentJapan
Study typeInterventional
Intervention(s)In the nicorandil group, after a bolus injection of nicorandil(0.067 mg/kg), it is continuously infused intravenously at 1.67ug/kg·min for 24h. In the control group, seline is continuously infused intravenously for 24h.


Primary Outcome(1) estimated infarct size and (2) left ventricular function (left ventricular ejection fraction and end-diastolic volume) and regional wall motion.
Secondary Outcome(1) survival rate (2)cardiovascular events (ie, cardiac death, nonfatal re-infarction, re-hospitalization because of cardiac disease, revascularization) (3) reperfusion injury (ie, malignant ventricular arrhythmia during reperfusion periods, re-elevation of ST-segment, worsening of chest pain) (4) the association of SNPs of ANP-related genes with response to ANP treatment

Key inclusion & exclusion criteria

Age minimum20years-old
Age maximum79years-old
GenderMale and Female
Include criteria
Exclude criteria1. History of old myocardial infarction 2. Left main coronary artery stenosis 3. Severe liver and/or kidney dysfunction 4. Suspected aortic dissection 5. History of coronary artery bypass graft 6. History of allergic response to drugs 7. Severe hypovolemia 8. Right ventricular infarction

Related Information


public contact
Address Japan
Telephone 06-6836-0077
Affiliation Clinical Study Support Center Japan (CSSCJ) J-WIND office
scientific contact
Name Masafumi Kitakaze
Address 5-7-1 Fujishirodai, Suita City, Osaka Pref. 565-8565, Japan Japan
Telephone 06-6833-5012
Affiliation National Cardiovascular Center Cardiovascular Division