UMIN ID: C000000077
Registered date:01/01/2006
Role of Thymidine Phosphorylase(TP), Dihydropyrimidine Dehydrogenase(DPD)and Thymidylate synthase(TS)for Predicting the Prognosis and Therapeutic Effects of Doxifluridine, An Intermediate form of Capecitabine, in adjuvant therapy for postoperative Node positive colorectal cancer(DukesC); Findings from a multicenter Phase2 trial.
Basic Information
| Recruitment status | Complete: follow-up continuing |
|---|---|
| Health condition(s) or Problem(s) studied | Dukes'C colorectal cancer which is removed curatively and surgically |
| Date of first enrollment | 2001/11/01 |
| Target sample size | 300 |
| Countries of recruitment | Japan |
| Study type | Interventional |
| Intervention(s) | chemotherapy(Doxifluridine:5'-DFUR) |
Outcome(s)
| Primary Outcome | Disease-free survival |
|---|---|
| Secondary Outcome | Overall survival |
Key inclusion & exclusion criteria
| Age minimum | 20years-old |
|---|---|
| Age maximum | 75years-old |
| Gender | Male and Female |
| Include criteria | |
| Exclude criteria | appendiceal carcinoma and anal canal carcinoma of anal gland origin Multiple cancer patients except m cancer apparent infection sever postoperative complications active peptic ulcer Cardiac infarction within three months-uncontrolled hypertension -diabetes mellitus, uncontrolled or controlled with insulin -unstable angina, myocardial infarction needed to treat or febrile neutropenia |
Related Information
| Primary Sponsor | Multicenter Clinical Study Group of Osaka |
|---|---|
| Secondary Sponsor | |
| Source(s) of Monetary Support | Multicenter Clinical Study Group of Osaka |
| Secondary ID(s) |
Contact
| public contact | |
| Name | Hirofumi Yamamoto |
| Address | 2-2 Yamadaoka Suita-City Osaka Japan |
| Telephone | 06-6879-3251 |
| hyamamoto@gesurg.med.osaka-u.ac.jp | |
| Affiliation | Multicenter Clinical Study Group of Osaka,Colorectal Cancer Treatment Group Coordinating Office |
| scientific contact | |
| Name | Morito Monden |
| Address | 2-2 Yamadaoka Suita-City Osaka Japan |
| Telephone | 0668793251 |
| hyamamoto@gesurg.med.osaka-u.ac.jp | |
| Affiliation | Osaka University Graduate School of Midicine Department of Surgery And Clinical Oncology |