JRCT ID: jRCTs041220129
Registered date:27/01/2023
Efficacy of NMN for tinnitus
Basic Information
Recruitment status | Recruiting |
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Health condition(s) or Problem(s) studied | tinnitus |
Date of first enrollment | 27/01/2023 |
Target sample size | 60 |
Countries of recruitment | |
Study type | Interventional |
Intervention(s) | Oral administration of NMN 6 tablets/day (as NMN 250mg /day) or placebo 6 tablets/day for 12 weeks. |
Outcome(s)
Primary Outcome | TRSw |
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Secondary Outcome | TRSd, THI-12, HADS |
Key inclusion & exclusion criteria
Age minimum | >= 20age old |
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Age maximum | <= 80age old |
Gender | Both |
Include criteria | 1) The first onset chronic, persistent, and subjective unilateral tinnitus whose duration is 2-18 months. 2) Age-related sensorineural hearing loss, with a hearing loss no less than 30 dB at 4,000 Hz or at 8,000 Hz 3) THI-12 total score no less than 9 and TRSw total score no less than 12 4) HADS depression score no more than 14 and HADS anxiety score no more than 14 |
Exclude criteria | a. Person with past or current malignant tumor b. Person with severe comorbidities, such as heart, liver, kidney, blood, or mental diseases c. Person with allergy against medicine or the test food d. Pregnant, unwilling to practice contraception during the study, or lactating female e. Person with middle ear disease f. Person with conductive hearing loss, mixed hearing loss, or sensorineural hearing loss excluding age-related hearing loss g. Person taking drug or supplement which contains nicotinamide, nicotinic acid, or NMN h. Person who is not judged as not qualified by the medical doctor. |
Related Information
Primary Sponsor | Takakura Hiromasa |
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Secondary Sponsor | |
Source(s) of Monetary Support | |
Secondary ID(s) |
Contact
Public contact | |
Name | Takashi Nakagawa |
Address | 2630 Sugitani, Toyama, Toyama, Japan Toyama Japan 930-0194 |
Telephone | +81-76-434-7262 |
nakagawa@med.u-toyama.ac.jp | |
Affiliation | University of Toyama |
Scientific contact | |
Name | Hiromasa Takakura |
Address | 2630 Sistani, Toyama, Toyama, Japan Toyama Japan 930-0194 |
Telephone | +81-76-434-7368 |
hiromasa@med.u-toyama.ac.jp | |
Affiliation | Toyama University Hospital |