NIPH Clinical Trials Search

JAPANESE
国立保健医療科学院
JRCT ID: jRCTs041220129

Registered date:27/01/2023

Efficacy of NMN for tinnitus

Basic Information

Recruitment status Recruiting
Health condition(s) or Problem(s) studiedtinnitus
Date of first enrollment27/01/2023
Target sample size60
Countries of recruitment
Study typeInterventional
Intervention(s)Oral administration of NMN 6 tablets/day (as NMN 250mg /day) or placebo 6 tablets/day for 12 weeks.

Outcome(s)

Primary OutcomeTRSw
Secondary OutcomeTRSd, THI-12, HADS

Key inclusion & exclusion criteria

Age minimum>= 20age old
Age maximum<= 80age old
GenderBoth
Include criteria1) The first onset chronic, persistent, and subjective unilateral tinnitus whose duration is 2-18 months. 2) Age-related sensorineural hearing loss, with a hearing loss no less than 30 dB at 4,000 Hz or at 8,000 Hz 3) THI-12 total score no less than 9 and TRSw total score no less than 12 4) HADS depression score no more than 14 and HADS anxiety score no more than 14
Exclude criteriaa. Person with past or current malignant tumor b. Person with severe comorbidities, such as heart, liver, kidney, blood, or mental diseases c. Person with allergy against medicine or the test food d. Pregnant, unwilling to practice contraception during the study, or lactating female e. Person with middle ear disease f. Person with conductive hearing loss, mixed hearing loss, or sensorineural hearing loss excluding age-related hearing loss g. Person taking drug or supplement which contains nicotinamide, nicotinic acid, or NMN h. Person who is not judged as not qualified by the medical doctor.

Related Information

Contact

Public contact
Name Takashi Nakagawa
Address 2630 Sugitani, Toyama, Toyama, Japan Toyama Japan 930-0194
Telephone +81-76-434-7262
E-mail nakagawa@med.u-toyama.ac.jp
Affiliation University of Toyama
Scientific contact
Name Hiromasa Takakura
Address 2630 Sistani, Toyama, Toyama, Japan Toyama Japan 930-0194
Telephone +81-76-434-7368
E-mail hiromasa@med.u-toyama.ac.jp
Affiliation Toyama University Hospital