vitamin D administration on chronic liver disease

JRCT ID: jRCTs031200015

Registered date:15/04/2020

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: chronic liver disease
• Date of first enrollment: 15/04/2020
• Target sample size: 200
• Study type: Interventional
• Intervention(s): Administration of BCAA preparation and Vitamin D supplement 2000 IU / day

Outcome(s)

• Primary Outcome: Skeletal muscle mass, grip, Liver fibrosis

Key inclusion & exclusion criteria

• Age minimum: >= 20age old
• Age maximum: < 85age old
• Gender: Both

Include criteria

Patients with chronic liver disease
20 years old or older, under 85 years old
Both hospitalization / outpatient
Patients with serum 25 (OH) D3 concentration deficiency less than 20 ng / ml

Exclude criteria

Hepatic encephalopathy more than 3
Total bilirubin value >3 mg/dl
Patien with decrease of the protein composition ability in the liver
The patient allergic to milk
The patient who is nursing and pregnant
Patient with uncotrolled HCC or other malignant tumor
Uncontrolled heart failure patient
Uncontrolled hypertension or diabetes
Patient with Chronic renal failure
Patient of hypercalcemia
Patient with hyperthyroidism
Patient who already takes other vitamin D
Patien who takes the drug that combination with the vitamin D preparation is contraindicated
Patient with acute liver failure
Patient who were judged unsuitable by test responsibility doctor

Related Information

• Primary Sponsor: Okubo Tomomi