Evaluation of the effect of broccoli-supplements intake on blood antioxidant levels and search for new biomarkers

JRCT ID: jRCTs021210018

Registered date:06/07/2021

Basic Information

• Recruitment status: Complete
• Health condition(s) or Problem(s) studied: Healthy adults
• Date of first enrollment: 06/07/2021
• Target sample size: 30
• Study type: Interventional
• Intervention(s): Six broccoli-based supplements or placebo capsules per days will be taken for 14 days.

Outcome(s)

Primary Outcome

1. Antioxidant capacity of plasma (GSH, GSSH, GSH polysulfides, GSSG, Oxidized GSH polysulfides, GSH/GSSG, Cysteine (Cys), CysSSH, Cys polysulfides, Cystine, Oxidized Cys polysulfides, Cys/Cystine, Homocysteine, Homocysteine persulfide, Bis-S-HPE-AM, Bis-SS-HPE-AM, BAP)
2. Blood metabolites

Secondary Outcome

1.SFN absorption efficiency
2.Biochemical test (AST, ALT, T-Bil, gamma-GTP)
3.Relationship between SFN absorption efficiency and antioxidative level in plasma
4.Relationship between SFN absorption efficiency and metabolites in plasma

Key inclusion & exclusion criteria

• Age minimum: >= 20age old
• Age maximum: <= 35age old
• Gender: Both

Include criteria

Subjects who satisfies all follwing criteria.
1.Healthy adults aged >= 20 years to =< 35 years at the start of the trial.
2.Who can make self-judgment, voluntarily agree to participate to this trial, and provide written informed consent.
3.Those who are judged to have high SFN absorption efficiency in a preliminary study of 20-40 people.

Exclude criteria

1. Subjects who have food allergy to the test supplements
2. Subjects who are pregnant, will hope pregnancy, or breast-feed during the study period
3. Subjects who suffer from psychiatric disease or express psychiatric symptoms
4. Subjects who join other clinical trials
5. Subjects who are judged unsuitable for this trial by the principal investigator

Related Information

• Primary Sponsor: Itoh Ken
• Secondary Sponsor: Natural Wellness Research Department, Innovation Division, KAGOME, CO., LTD.