The Effect of High-Flow Nasal Cannula Oxygen Therapy on Respiratory Muscle

UMIN ID: UMIN000055470

Registered date:11/09/2024

Basic Information

• Recruitment status: Complete: follow-up continuing
• Health condition(s) or Problem(s) studied: Patients 18 years of age or older for whom HFNC is considered appropriate at the time of consent. Patients with acute respiratory failure (PaO2/FIO2<300, SpO2<92%, etc. requiring oxygenation). High risk post extubation (age > 65 years, chronic heart failure, APACHE II score > 12, BMI > 30, airway problems, difficult weaning, duration of ventilator management > 7 days). Post thoracic surgery (ARISTAT score > 26 points, obesity, high risk of cardiac and pulmonary disease).
• Date of first enrollment: 2022/10/11
• Target sample size: 30
• Countries of recruitment: Japan
• Study type: Observational

Outcome(s)

• Primary Outcome: The results of this study will evaluate the changes in DTei, DTee, ETei, ETee, DTF, ETF, DTF/respiratory rate, and ETF/respiratory rate before and after wearing HFNC as changes in respiratory effort. In addition, the relationship between inspiratory and expiratory muscles will be evaluated.

Key inclusion & exclusion criteria

• Age minimum: 18years-old
• Age maximum: 100years-old
• Gender: Male and Female
• Exclude criteria: Highly obese (BMI>40), pregnant women, history of neuromuscular disease, cervical cord injury or post-surgical spinal cord injury, abdominal obstruction, post-tracheostomy, severe COPD, overactive delirium, agitation

Related Information

• Primary Sponsor: Tokushima University
• Source(s) of Monetary Support: none