Verification of the effect of sacubitril valsartan sodium hydrate on the residual renal function of peritoneal dialysis patients

UMIN ID: UMIN000048227

Registered date:01/07/2022

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: End-stage renal failure
• Date of first enrollment: 2022/07/01
• Target sample size: 45
• Countries of recruitment: Japan
• Study type: Interventional

Intervention(s)

Test group: Sacubitril valsartan sodium hydrate use group.
ARB group: RAS inhibitor use group.
Control group: Sacubitril valsartan sodium hydrate and no RAS inhibitor.

Outcome(s)

• Primary Outcome: Comparison of the rate of decrease in residual renal function in each group after 6 months of distribution to 3 groups.
• Secondary Outcome: Comparison of blood pressure in each group after 6 months of distribution to 3 groups .Comparison of cardiac function (EF) by Biplane Modified Simpson method in each group after 6 months of 3 groups.Comparison of peritoneal function in each group after 6 months of distribution to 3 groups.

Key inclusion & exclusion criteria

• Age minimum: 20years-old
• Age maximum: 90years-old
• Gender: Male and Female
• Exclude criteria: Those who did not consent to participate in the study.

Related Information

• Primary Sponsor: International University of Health and Welfare
• Source(s) of Monetary Support: International University of Health and Welfare