Effect of individualized blood pressure management on postoperative outcomes in hypertensive patients undergoing major surgery

UMIN ID: UMIN000048163

Registered date:25/06/2022

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: Hypertensive patients undergoing major surgery
• Date of first enrollment: 2022/07/01
• Target sample size: 400
• Countries of recruitment: Japan
• Study type: Interventional

Intervention(s)

Intraoperative individualized blood pressure management to maintain mean blood pressure within 10% of the reference value
Intraoperative blood pressure management to maintain mean blood pressure 65mmHg or higher.

Outcome(s)

• Primary Outcome: Incidence of postoperative acute kidney injury

Key inclusion & exclusion criteria

• Age minimum: 20years-old
• Age maximum: Not applicable
• Gender: Male and Female
• Exclude criteria: 1. Emergency cases 2. Patients who will receive mechanical ventilation after surgery 3. Preoperative acute kidney injury (preoperative eGFR<30 ml/min/1.73m2) 4. Kidney surgery 5. Surgery requiring hypotensive management 6. Preoperative mean blood pressure less than 75mmHg

Related Information

• Primary Sponsor: Osaka Metropolitan University Graduate School of Medicine
• Secondary Sponsor: Department of Anesthesiology, Osaka city general hospital
• Source(s) of Monetary Support: Self funding