Comparison of reversal with neostigmine vs. sugammadex for postoperative bowel function in patients undergoing colorectal surgery

UMIN ID: UMIN000043518

Registered date:14/09/2021

Basic Information

• Recruitment status: Complete: follow-up complete
• Health condition(s) or Problem(s) studied: colorectal surgery
• Date of first enrollment: 2022/05/12
• Target sample size: 122
• Countries of recruitment: Asia(except Japan)
• Study type: Interventional

Intervention(s)

sugammadex
neostigmine

Outcome(s)

• Primary Outcome: Evaluating the time taken to expel gas in the first intestine after surgery

Key inclusion & exclusion criteria

• Age minimum: 19years-old
• Age maximum: Not applicable
• Gender: Male and Female
• Exclude criteria: 1. Patients who have been given drugs that affect muscle relaxation recovery (anticonvulsants, antidepressants, etc.) 2. Patients who had history of neuromuscular diseases 3. Patients with hypersensitivity to rocuronium, neostigmine, and sugammadex 4. Patients with liver disease (OT/PT> 40 IU/L), kidney disease (Cr> 1.4 mg/dl) 5. Patients with with bowel obstruction 6. Patients who disagree with the test

Related Information

• Primary Sponsor: self
• Source(s) of Monetary Support: MSD Korea Ltd.(MSD has decided to offer sugammadex drugs in-kind.)