Development of objective measures for depression, bipolar disorder and dementia by quantifying facial expression, body movement and voice data: A pilot study

UMIN ID: UMIN000021396

Registered date:08/03/2016

Basic Information

• Recruitment status: Complete: follow-up complete
• Health condition(s) or Problem(s) studied: 1. Patients with depressive disorder or bipolar disorder 2. Patients with dementia, mild cognitive impairment, or subjective cognitive impairment 3. Healthy volunteers
• Date of first enrollment: 2016/03/10
• Target sample size: 20
• Countries of recruitment: Japan
• Study type: Interventional
• Intervention(s): Video/infrared/voice recording during 10 minutes conversation with psychiatrist and/or psychologist. Total number of recording will be 5 times or less. Recording will be done on the doctor visit and the interval of the recording will not be fixed (20 days or longer for healthy volunteers). Clinical severity assessment using rating scales as follows. Hamilton Rating Scale for Depression (HAM-D): 20 minutes Montgomery Asberg Depression Rating Scale (MADRS): 10 minutes Young mania rating scale (YMRS): 10 minutes Beck depression inventory (BDI): 3 minutes pittsburgh sleep quality index (PSQI): 2 minutes Clinical Dementia Rating(CDR): 15 minutes Mini-mental Scale Examination (MMSE): 15 minutes Wechsler Memory Scale-Logical Memory Subtest: 5 minutes Clock drawing test (CDT): 3 minutes Neuropsychiatric Inventory (NPI): 10minutes Geriatric Depression Scale (GDS): 5 minutes

Outcome(s)

• Primary Outcome: To examine the feasibility and safety of data collection according to the current protocol.

Key inclusion & exclusion criteria

• Age minimum: 20years-old
• Age maximum: Not applicable
• Gender: Male and Female
• Exclude criteria: As patients (1) Patients whose illness can be exacerbated by the interview of the study. (2) Patients who have comorbidities that can interfere with the measurements in the study; such as patients with facial palsy or involuntary movement, patients with quadriplegic palsy or involuntary motion, patients with dysphonia by laryngectomized. (3) Those who are considered to be ineligible by the PI or investigators. As healthy volunteers (2) and (3) described above

Related Information

• Primary Sponsor: Keio University School of Medicine
• Secondary Sponsor: Keio University Science and Technology Omron corporation Advanced Media corporation FRONTEO Healthcare, Inc.
• Source(s) of Monetary Support: Japan Agency for Medical Research and Development (AMED)