UMIN ID: UMIN000002080
Registered date:16/06/2009
A clinical research regarding an inhalation therapy of the low concentration carbon monoxide (CO) in patients with chronic obstructive pulmonary disease (COPD) and secondary pulmonary artery hypertension (sPAH)
Basic Information
| Recruitment status | Complete: follow-up complete |
|---|---|
| Health condition(s) or Problem(s) studied | COPD and sPAH |
| Date of first enrollment | 2006/06/01 |
| Target sample size | 20 |
| Countries of recruitment | Japan |
| Study type | Interventional |
| Intervention(s) | low dose carbon monoxide inhalation (50-100 ppm) |
Outcome(s)
| Primary Outcome | Mean pulmonary artery pressure |
|---|---|
| Secondary Outcome | Dyspnea scale (Hugh-Jones scale), distance in 6 minutes walking test, lung function, lipid peroxide, and peripheral blood IL-10 level |
Key inclusion & exclusion criteria
| Age minimum | 40years-old |
|---|---|
| Age maximum | Not applicable |
| Gender | Male and Female |
| Include criteria | |
| Exclude criteria | 1.Patients exposed to high level of ambient CO whose arterial Hb-CO (aHb-CO) concentration was more than 3.0% 2.Current smoker within 4 weeks 3.Patients with cardiac, hepatic, or hematologic diseases 4.Patients with abnormalities of blood coagulation or fibrinolysis |
Related Information
| Primary Sponsor | Tohoku University |
|---|---|
| Secondary Sponsor | |
| Source(s) of Monetary Support | Grant-In-Aid for Scientific Research |
| Secondary ID(s) |
Contact
| public contact | |
| Name | |
| Address | Japan |
| Telephone | |
| Affiliation | Tohoku University Department of Translational Research Center |
| scientific contact | |
| Name | Hiroyasu Yasuda |
| Address | 1-1 Seiryo-machi, Aoba-ku, Sendai, Japan Japan |
| Telephone | |
| Affiliation | Tohoku University Department of Translational Research Center |