UMIN ID: UMIN000002079
Registered date:01/07/2009
Multi-center open labeled trial on effects of candesartan on heart rate and blood pressure in the early morning in patients with hypertension
Basic Information
Recruitment status | Complete: follow-up complete |
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Health condition(s) or Problem(s) studied | Hypertension |
Date of first enrollment | 2008/09/01 |
Target sample size | 100 |
Countries of recruitment | Japan |
Study type | Interventional |
Intervention(s) | In patients with hypertension treating with ARBs other than candesartan with blood pressure more than 135/85 mmHg, we will change ARBs to candesartan and follow up for 1 year. When we change ARBs to candesartan , we regard that candesartan 4mg corresponds to losartan 25mg, valsartan 40mg, telmisartan 20mg and olmesartan 10mg, respectively. Maximal dose of each ARB corresponds to candesartan 12mg. |
Outcome(s)
Primary Outcome | Home blood pressure and heart rate in the early morning Ratio of morning and evening blood pressure (M/E ratio) |
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Secondary Outcome | Seasonal change in blood pressure |
Key inclusion & exclusion criteria
Age minimum | 20years-old |
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Age maximum | Not applicable |
Gender | Male and Female |
Include criteria | |
Exclude criteria | 1)Patient with allergy to candesartan or amlodipine 2)Pregnant woman or possible pregnant woman 3)Patients with maximal dose of candesartan or amlodipine 4)Patients receiving Ca channel blockers other than amlodipine 5)Patients with atrial fibrillation or its past history |
Related Information
Primary Sponsor | Gifu university graduate school of medicine, department of cardiology |
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Secondary Sponsor | |
Source(s) of Monetary Support | Gifu university graduate school of medicine |
Secondary ID(s) |
Contact
public contact | |
Name | Shinya Minatoguchi |
Address | Yanagido1-1 Japan |
Telephone | 058-230-6520 |
minatos@gifu-u.ac.jp | |
Affiliation | Gifu university graduate school of medicine Cardiology |
scientific contact | |
Name | Shinya Minatoguchi |
Address | Yanagido 1-1, Gifu city Japan |
Telephone | 058-230-6520 |
minatos@gifu-u.ac.jp | |
Affiliation | Gifu university graduate school of medicine Cardiology |