NIPH Clinical Trials Search

JAPANESE
国立保健医療科学院
UMIN ID: UMIN000002079

Registered date:01/07/2009

Multi-center open labeled trial on effects of candesartan on heart rate and blood pressure in the early morning in patients with hypertension

Basic Information

Recruitment status Complete: follow-up complete
Health condition(s) or Problem(s) studiedHypertension
Date of first enrollment2008/09/01
Target sample size100
Countries of recruitmentJapan
Study typeInterventional
Intervention(s)In patients with hypertension treating with ARBs other than candesartan with blood pressure more than 135/85 mmHg, we will change ARBs to candesartan and follow up for 1 year. When we change ARBs to candesartan , we regard that candesartan 4mg corresponds to losartan 25mg, valsartan 40mg, telmisartan 20mg and olmesartan 10mg, respectively. Maximal dose of each ARB corresponds to candesartan 12mg.

Outcome(s)

Primary OutcomeHome blood pressure and heart rate in the early morning Ratio of morning and evening blood pressure (M/E ratio)
Secondary OutcomeSeasonal change in blood pressure

Key inclusion & exclusion criteria

Age minimum20years-old
Age maximumNot applicable
GenderMale and Female
Include criteria
Exclude criteria1)Patient with allergy to candesartan or amlodipine 2)Pregnant woman or possible pregnant woman 3)Patients with maximal dose of candesartan or amlodipine 4)Patients receiving Ca channel blockers other than amlodipine 5)Patients with atrial fibrillation or its past history

Related Information

Contact

public contact
Name Shinya Minatoguchi
Address Yanagido1-1 Japan
Telephone 058-230-6520
E-mail minatos@gifu-u.ac.jp
Affiliation Gifu university graduate school of medicine Cardiology
scientific contact
Name Shinya Minatoguchi
Address Yanagido 1-1, Gifu city Japan
Telephone 058-230-6520
E-mail minatos@gifu-u.ac.jp
Affiliation Gifu university graduate school of medicine Cardiology