Usefullness of non-invasive biomarkers in the treatment wiht bronchial asthma

UMIN ID: UMIN000001768

Registered date:12/03/2009

Basic Information

• Health condition(s) or Problem(s) studied: Bronchial asthma
• Date of first enrollment: 2009/02/01
• Target sample size: 60
• Countries of recruitment: Japan
• Study type: Interventional
• Intervention(s): Inhaled bronchodilator; salbutamol

Outcome(s)

• Primary Outcome: 1.Routine respiratory function tests: spirometry,body plethysmography and closing volume at atable period, before and 15min after inhaled bronchodilator during mild exacerbation. 2.Non-invasive biomarker; impulse oscillometry: R5,R20,R5-R20,X5,AX, and exhaled nitric oxide at stable period, before and 15min after inhaled bronchodilator during mild exacerbation.
• Secondary Outcome: Scores of questionnaires for QOL

Key inclusion & exclusion criteria

• Age minimum: 20years-old
• Age maximum: 80years-old
• Gender: Male and Female
• Exclude criteria: 1. Obstructive pulmonary disease; COPD, bronchiectasis, choronic bbronchitis 2. Tuberculosis, other respiratory infection 3. Allergy for salbutamol 4. Pregnancy and lactation 5. Moderate and severe asthma exacerbation 6. inappropriate patients from the doctor's viewpoint

Related Information

• Primary Sponsor: Third Department of Internal medicine, Sapporo Medical University School of Medicine
• Secondary Sponsor: none
• Source(s) of Monetary Support: Third Department of Internal medicine, Sapporo Medical University School of Medicine,none